Sunitinib Produces Neuroprotective Effect Via Inhibiting Nitric Oxide Overproduction
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چکیده
منابع مشابه
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PURPOSE To investigate the effect of nipradilol, an alpha(1),beta-blocker with a nitric oxide donative action, on N:-methyl-D-aspartate (NMDA)-induced retinal damage in rats and to determine whether topically instilled nipradilol penetrates the ipsilateral posterior retina-choroid at pharmacologically active concentrations in rabbits. METHODS To determine effects on NMDA-induced damage, drugs...
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BACKGROUND Inhaled nitric oxide (iNO) is one of the most promising therapies used in neonates. However, little information is known about its impact on the developing brain submitted to excitotoxic challenge. METHODOLOGY/PRINCIPAL FINDINGS We investigated here the effect of iNO in a neonatal model of excitotoxic brain lesions. Rat pups and their dams were placed in a chamber containing 20 ppm...
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ژورنال
عنوان ژورنال: CNS Neuroscience & Therapeutics
سال: 2014
ISSN: 1755-5930
DOI: 10.1111/cns.12203